Laboratory Animal Metabolism

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Labcorp has a long history of conducting standard and tailored metabolism studies for a wide range of crop protection products

An established team of metabolism scientists with scientific insights and practical expertise accumulated over years working in the crop protection product and testing industry

Flexible facilities that can accommodate a wide range of test species, to high welfare standards

Metabolism studies (toxicokinetics) in animal models allow you to establish the absorption, distribution, metabolism and excretion (ADME) of your crop protection product. Data from animal metabolism studies are essential for the assessment of the human hazard and/or risk posed by your crop protection product.

How best to optimize your animal metabolism studies?

Metabolism studies in laboratory animals are usually straightforward; however, there are still multiple things to consider. Which species is appropriate and are multiple species required? What about dosing — how often and by what route?

Standard and specialty studies, including inhalation ADME

As well as the standard OECD 417: Toxicokinetic studies, Labcorp has expertise in the design and performing of tailored studies. For example, studies can be tailored for:

  • Species: rat, mouse, rabbit, dog, primate and minipig
  • Dose administration: including oral, dermal, IV or inhalation administration for single or repeat dosing
  • Sample collection including bile duct and duodenal cannulation in rats and dogs for biliary excretion and portal artery/vein cannulation to investigate hepatic first-pass metabolism

Full range of toxicokinetic analysis

Labcorp provides a full range of toxicokinetic assessments including:

  • Excretion/balance
  • Pharmacokinetics
  • Tissue distribution, including quantitative whole-body audioradiography (QWBA)
  • Biliary excretion
  • Metabolite profiling and identification

Innovating to enhance animal welfare standards

Labcorp works tirelessly to ensure the optimum welfare standards are maintained. In addition, our working with NC3Rs and other CROs to refine the bile duct cannulation (BDC) model to further enhance animal welfare, reduces numbers while ensuring a robust model with high scientific integrity.

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