In Vitro Alternative Test Methods

Proven expertise in delivering high-quality in vitro safety assessments

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Over 20 years’ experience in designing and conducting a comprehensive suite of in vitro tests to globally recognized standards

Innovators in in vitro study design and technology: enhancing study reliability and improving outcomes

Insights gathered from worldwide regulatory environments leveraged to smooth the regulatory journey of your crop protection product

Labcorp is committed to driving the 3Rs agenda and offering New Approach Methods (NAMs) – non-animal approached – as demonstrated by our innovation of in vitro testing for the assessment of crop protection products. By partnering with us you will benefit from both our vast experience conducting standard techniques as well as our novel solutions. We’ll create an approach tailored to your regulatory needs and aligned to your substance’s specific properties.

In vitro safety assessments

Multiple in vitro test methods are available for ascertaining the potential impact of your crop protection product on human safety; however how do you find the optimum approach to meet your needs? How can you best exploit in silico and in vitro testing to answer regulatory questions and meet ever-changing endpoints? You need a partner with insight and experience in in vitro test methods and their application to different global regulatory environments..

Labcorp is at the forefront of in vitro testing for crop protection products

Labcorp has played a role in validating various in vitro technologies. Staff engage proactively with the in vitro scientific community via membership of a range of professional bodies such as the in vitro toxicology society (IVTS), in vitro testing industrial platform (IVTIP) and the European Society of Toxicology In Vitro (ESTIV).

This puts us at the forefront of in vitro methodologies and innovations, generating insights that benefit you as our partner.


A unique stem cell-based reporter assay for reliable genotoxicity and carcinogenicity hazard identification

A highly reliable detection of genotoxic compounds, the ToxTracker assay provides you insight into the mode-of-action of genotoxicity. The assay can discriminate between direct DNA reactivity and indirect genotoxicity related to oxidative stress or protein damage and can identify clastogenic and aneugenic compounds. Use of the ToxTracker assay can help you mitigate risk of regulatory rejection by providing data concerning the mechanism of genotoxicity.

Partner with an expert team dedicated to delivering in vitro testing success

The in vitro testing team comprises experts from varied backgrounds with extensive experience in planning and managing in vitro tests. The team includes toxicologists, biologists, analytical chemists and environmental scientists. By working collaboratively, study plans can be flexed and optimized to meet your needs and timelines.

Let Labcorp leverage their extensive in vitro testing capabilities to reliably characterize the safety profile of your crop protection product

We conduct approximately 400 in vitro toxicology studies each year covering the following:


Balb/c 3T3

OECD 432


Balb/c; L929; MRC5


Skin Corrosion

3D models

OECD 431


OECD 435

Skin Irritation

3D models

OECD 439

Eye Irritation

Eye Hazard Identification Test using the Reconstructed Human Cornea-like Epithelium (RHCE) Model


Skin Sensitization

Direct Peptide Reactivity Assay (DPRA)


Kinetic Direct Peptide Reactivity Assay (kDPRA)

OECD 442C (Annex III)

KeratinoSens™ Assay


Human Cell Line Activation Test (hCLAT)


 Endocrine Disruption

Estrogen receptor agonist/antagonist

OECD 455

H295R Steroidogenesis assay

OECD 456
Androgen receptor (AR Calux®) agonist/antagonist OECD 458

Human Recombinant Estrogen Receptor (hrER)

OECD 493


Bhas42 in vitro Cell Transformation Assay


Toxicity (genetic) mode of action


*In Vivo Skin Sensitisation (OECD 429B) can be offered when justified

‡GLP offering. OECD Test Guideline application in progress.

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